Kambo's primary active components are peptides – short chains of amino acids – that act as natural messengers within the body. These peptides interact with specific receptors, initiating biological responses that support the body's natural processes. Kambo secretion contains a diverse array of bioactive compounds, including over 70 identified peptides, many of which are being investigated for their potential uses. It's important to note that research is ongoing, and the full spectrum of Kambo's components may not yet be fully understood.

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Key Peptides and Their Biological Effects:

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Here's a look at some of the key peptides found in Kambo and their known or suspected actions. While we aim to be comprehensive, it's possible that not every peptide has been fully identified or characterised. The exact composition can also vary slightly.

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Opioid Peptides (Dermorphin, Deltorphin)

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• These peptides interact with opioid receptors in the nervous system and are the subject of ongoing research into their role in the body's natural comfort and regulatory processes.

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Caerulein and Phyllocaerulein

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• These peptides are understood to support smooth muscle function, contributing to the body's natural digestive and cleansing processes. They are also being researched for their potential role in supporting the body's natural response to inflammation.

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Sauvagine

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• This peptide interacts with the hypothalamic-pituitary-adrenal (HPA) axis, which plays a role in the body's natural stress response, cortisol regulation, and sense of calm and relaxation.

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Dermaseptins (including Dermaseptin B2, B3, and B4)

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• These peptides have broad-spectrum antimicrobial properties, supporting the body's natural defences against bacteria, fungi, and viruses. They are the subject of ongoing scientific research into their wider biological effects.

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Adenoregulin

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• This peptide is believed to support healthy circulation and the body's natural inflammatory response. It may also play a role in supporting cellular energy.

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Phyllokinin

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• This peptide acts as a vasodilator, supporting the relaxation of blood vessels and healthy circulation.

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Phyllomedusin

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• This peptide supports smooth muscle function, contributing to Kambo's effects on the body's natural digestive processes.

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Phyllolitorin

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• Similar to caerulein, this peptide supports smooth muscle function and may play a role in the body's natural gastric processes.

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Neurokinin B

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• This peptide is involved in various physiological processes, including natural neurotransmission and the body's inflammatory response.

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Bradykinin-related peptides

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• These peptides support vasodilation, contributing to healthy circulation.

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Bombesin and Bombesin-like peptides

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• These peptides support gastrointestinal function and may play other natural regulatory roles in the body.

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Tryptophan-related peptides

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• These peptides are being explored for their potential antioxidant and anti-inflammatory supporting properties.

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Other Peptides

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• Research continues to identify and characterise additional peptides in Kambo, with ongoing investigation into their potential effects on the body's natural immune, nervous, and physiological processes.